Q. I know that someone who is sick enough to have to lay in bed can take take pills for pain during Shabbat . If one has difficulty in swallowing the pills can they be dissolved in a liquid?
A. Shulchan Aruch (O. H. 321: 12) rules that there is no grinding after grinding, and the pills are made from solidified powders. Shemiras Shabbos K’ (33: 4), permits to grind the pill and then dissolve them in liquid.
Horav Shlomo Miller’s Shlit’a opinion is that it should be dissolved in enough liquid to make it watery.
Rabbi A. Bartfeld as revised by Horav Dovid Pam, Horav Aharon Miller and Horav Chanoch Ehrentreu Shlit’a