Q. If I send shalach monos to someone and they were only delivered to his home when he was already in a situation of totally “ad delo yoda” and most likely was potur from mitzvos, do I comply with the mitzva?

A. Mishne Halochos (4: 90) writes that if he reached the stage of inebriation of Lot were he is not conscious of his actions, he is exempt at that stage of mitzvos and the one sending shalach monos to him would not comply with the mitzvah. However he adds, if he is asleep and may recover still during Purim, he may indeed comply.
Horav Shlomo Miller’s Shlit”a opinion is that the sender complies with the mitzva.

Rabbi A. Bartfeld as revised by Horav Shlomo Miller Shlit”a.